Factsheet: RHDV-2 in Australia and implications for current rabbit biocontrol initiatives

Rabbit haemorrhagic disease virus (RHDV), previously known as rabbit calicivirus, has been used as a biocontrol for rabbits in Australia since 1996. Researchers have discovered several different strains or variants of RHDV, but not all have the same effect on wild rabbits in Australia.

RHD resistance

The strain used for rabbit control in Australia since 1996 is RHDV1 from Czech Republic. Over time, rabbits have developed genetic resistance to RHDV1 and its effectiveness as a biocontrol agent has been reduced. The Invasive Animals CRC’s RHD Boost project has been investigating whether other RHDV1 variants sourced from overseas can overcome this resistance and be used to ‘boost’ rabbit biocontrol in Australia. One strain from Korea (RHDV1 K5) has been found to be a good candidate.

In May 2015, RHDV2 virus was found in wild rabbits in the ACT, and has since been discovered across NSW, SA and VIC.  This new virus is referred to as RHDV2 because the mode of death is the same as RHDV1, however they are two separate viruses.  In contrast to RHDV1, RHDV2 can cause death in young rabbit kittens (3-4 weeks) and vaccinated adults. The currently available vaccine is not fully protective against disease from RHDV2. While a new vaccine is being developed for RHDV2, a revised vaccination protocol using the current vaccine is now available on the AVA website and we recommend to contact your veterinarian for further advice.

RHDV2 has been reported to infect certain sub-species of hares in Europe as well as rabbits. In June 2016 it was confirmed in a small number of European Brown Hares in Australia, the only hare species present here. It is currently unclear if these were rare spillover infections from rabbits to hares, or if RHDV2 actually spreads effectively between hares as it does between rabbits.

In December 2013 an RHDV1-type Chinese strain was also found in NSW and later in the ACT, but this virus has not been widely reported since.

VIDEO: Dr Tanja Strive talks about genetic resistance, immunity and transmission associated with RHDV in Australia.

Studies in Europe suggest that RHDV2 has a strong competitive advantage over the earlier viruses. It appears to be replacing previous RHDV strains in parts of Europe, and recent reports suggest that rabbit numbers in Europe have been trending down since the arrival of RHDV2. Its potential to spread rapidly is likely aided by its ability to infect rabbits that are vaccinated or immune to field strains, and possibly the ability to infect younger rabbits.  If the RHDV2 present in Australia is highly virulent, it could potentially benefit rabbit control in Australia as it may overcome immunity to circulating field strains of RHDV1. Alternatively, if it completely replaces existing strains but has lower virulence leading to increased survival of rabbits during virus outbreaks, it could lessen the impact of current and future biocontrol initiatives using RHDV1 in Australia.

The ability to overcome immunity to field strains also means that this virus may also be able to overcome vaccination. However, preliminary studies from Europe show that the commercially available vaccine at least partially protects against RHDV2, and protection is increased if regular boost vaccinations are applied. Keeping domestic or pet rabbits’ vaccinations up to date is therefore recommended to provide maximum possible protection against this new variant.

The effect of RHDV2 on biocontrol in Australia will largely depend on three properties of this virus:

  • its virulence 
  • its ability to infect young rabbits
  • its ability to overcome immunity to Australian field strains.

Estimating any of these effects of RHDV2 on Australian rabbits and current and planned biocontrol initiatives largely relies on a speedy and thorough characterisation of the RHDV2 variant isolated in Australia.

Rabbits_webIn addition, it remains critically important to continue and ramp up epidemiology and surveillance efforts, to determine the distribution of the new RHDV2 variant in Australia, its impact on wild rabbits and its interactions with viruses already established. For this purpose it is critical that specific serological diagnostic tools are developed to determine exposure of wild rabbit populations to the different viruses. The proposed release of the new RHDV1 K5 should be deferred until Autumn 2017 to first allow an evaluation of the distribution and potential impact of both RHDV2 and the RHDV1a Chinese strain, and to maximise the effectiveness of the release.

Finally, it is important to emphasise that biocontrol is only one tool available for land managers to manage rabbits. Control programs that complement biocontrol (usually baiting, warren ripping, and fumigation of missed or re-opened burrows in that order) are the best way to keep rabbit numbers very low. Should the spread of RHDV2 reduce the overall effectiveness of biological control, these methods will need to be brought to the fore even more. The present uncertainty shows the need for a timely review of pest control agencies to ensure that they have the capacity to train and offer advice on effective rabbit control especially if there were to be a lessening of effectiveness of biological control.


Link: Boosting rabbit biocontrol: RHDV K5 national release



Author Rabbit Biocontrol Scientific Committee
Year 2016
Publisher Invasive Animals CRC
Pages 4
ISBN/ISSN PestSmart code: RABFS9
Control method Biological Control
Region Australia - national

PestSmart Toolkit for rabbits: www.pestsmart.org.au/pest-animal-species/european-rabbit/


Download the full statement and recommendations from the Invasive Animals CRC Rabbit Biocontrol Scientific Committee [ 504 kb PDF ]