Mechanisms leading to permanent infertility in mice following immunisation with recombinant murine cytomegalovirus expressing murine zona pellucida 3

Immunocontraception is a promising biological control for wild mice in Australia, having the potential to reduce the socio-economic cost of plagues with minimal environmental impact. Inoculation of BALB/c mice with recombinant murine cytomegalovirus encoding murine zona pellucida antigen (mCMV-ZP3) confers total infertility characterised by depletion in ovarian tertiary follicles (Lloyd, et al., 2003). The mechanisms underlying ovarian pathology are largely unknown but are likely to involve antibody mediated and cell mediated immune responses. The immune pathology may also be facilitated by acute responses involving antibody binding to ZP in growing follicles resulting in recruitment of inflammatory cells and oocyte destruction. The aim of this study was to investigate the effect of mCMV-ZP3 infection on leukocyte infiltration and expression on oocyte-derived signalling molecules in ovarian tissue.

Author O'Leary, S., Lloyd, M. L., Shellam, G. R. and Maddocks, S.
Date 2005-05-02
Year 2005
Secondary title 13th Australasian Vertebrate Pest Conference
Place published Wellington, NZ
Publisher Landcare Research
Institution University of Adelaide
Pages 128-128
Control method Fertility Control
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